For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

The X contains more genes related to brain function than does any other chromosome. “The X chromosome may be a treasure trove of genes that influence cognition, and these could be therapeutic targets, ...

Stop the Spread. Injecting saline into mouse kidneys did not affect the left or right substantia nigra (top). Injecting fibrils of α-synuclein ablated about half of the dopaminergic neurons (middle ...

Sphere of Influence. In iAssembloids, microglia (red) form projections (white arrows), while astrocytes (green) assume star shapes typically found in the brain. [Courtesy of Kampmann et al., 2025.] ...

Michael Breakspear, M.B. B.S., B.Sc., B.A., FRANZCP, Ph.D. Newcastle, Australia ...

I have no competing interest.

Scientists consider Alzheimer’s disease to be a secondary tauopathy induced by amyloid plaques. Given that Aβ and tau start aggregating in different regions of the brain, how does one set off the ...

Scientists are seeking ways to tweak γ-secretase activity to turn down production of Aβ while leaving other substrates untouched. In the January 8 Nature Aging online, researchers led by Jee-Yin Ahn ...

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